This study presents the design and analysis of a specialized RF/MW circuit named the Quantum Non-classicality Enhancing Circuit, specifically developed for quantum applications. The primary objective is to reduce the noise figure within the operational frequency range of 4–8 GHz to enhance non-classical properties in quantum signals. To achieve this, a HEMT was chosen due to its exceptional noise reduction capabilities, which are critical for quantum engineering. While targeting a noise figure of less than 0.065 dB within the specified frequency band, a trade-off with gain was identified. This issue was addressed by introducing additional amplification stages to stabilize the noise figure without compromising overall performance. Quantum analysis of the circuit, based on a simplified HEMT model, provided valuable insights into its nonlinear behavior and the interaction between circuit components and environmental factors. Using the QuTiP toolbox in Python, a time-evolution analysis of the system was conducted, revealing the circuit’s response as an open quantum system under cryogenic conditions. The study also explores the relationship between quantum correlation (measured by quantum discord) and the noise figure, raising significant questions about the impact of noise minimization on enhancing non-classicality at low temperatures. Alongside the quantum analysis, a detailed circuit layout was designed and optimized to minimize the noise figure. The findings from the quantum analysis demonstrated that non-classicality generation and noise minimization share a common foundation, reinforcing the design approach. This comprehensive study highlights the complex interplay between circuit design and quantum properties, offering a strategic path toward improved quantum signal processing at cryogenic temperatures.