471 results found

Pitithat Puranachot, Thivaratana Sinthuwiwat, Priyavudh Herabutya, Kanthida Jangyubol, Bongkod Petcharat, Jutamas Yimnoon, Jitsopin Phadungsut, Chayanee Samdaengpan, Chumut Phanthunane

Background: Accurately predicting treatment outcomes in patients with advanced non-small cell lung cancer (NSCLC) remains a significant clinical challenge. While circulating tumor DNA (ctDNA) within p...

BMC Personalized Medicine 2026-04-21 rs-9258115
Liquid biopsy monitoring Cell-free DNA Non-small cell lung cancer Progression-free survival Copy-number alterations cfDNA fragmentation Low-coverage whole-genome sequencing

Abhijit Dutta, Dewan Md. Sumsuzzman, Daniel Wrzałko, Robbert van Haselen, Petra Weiermayer, Katharina Gaertner, J.A.D.S. Lakshani, Sabine Klein, Stephan Baumgartner, Martin Loef

Background: Insomnia is a prevalent disorder associated with substantial impairment. Homeopathy has been proposed as a complementary treatment for insomnia, but its clinical effects remain uncertain. ...

Research Square 2026-04-21 rs-9439398
Insomnia Homeopathy Systematic Review Meta-analysis Sleep disorders Funding: Software AG Stiftung Darmstadt Germany

Munesuishe Gotora, Ariana Mugore, Israel Sikumbili, Zainab Patel, Thom Kaledzera, Yohane Gadama, Reuben Kalavina, Nesto Tarimo

Background: Post-stroke depression is a common neuropsychiatric complication affecting stroke survivors worldwide, with a global prevalence of 20–50%. Establishing its prevalence and associated risk f...

Research Square 2026-04-21 rs-9287535
Depression Malawi Mental Health Stroke

Abdi Leta, Gamachu Diba

Background Oral administration is the preferred route for drug delivery due to convenience and patient compliance, yet its efficacy is hampered by low solubility and enzymatic degradation. Nanoparticu...

Research Square 2026-04-21 rs-9452361
nanoparticles oral bioavailability drug delivery systems pharmacokinetics

Aisha Ghazanfar, Saba Zaidi, Shafiq Ur Rehman, Hazim Brohi

Introduction: Pulmonary arteriovenous malformations (PAVMs) are abnormal vascular connections that predispose to paradoxical embolism and brain abscess formation. They often remain undetected until se...

Research Square 2026-04-21 rs-9335231
Hereditary Hemorrhagic Telangiectasia Brain abscess Pulmonary Arteriovenous Malformation paradoxical embolism

Tien Nguyen

Background Metabolic syndrome (MetS) is common in older adults and is associated with cardiovascular disease, type 2 diabetes, and functional decline. In Vietnam, evidence on MetS in older adults is s...

BMC Geriatrics 2026-04-21 rs-9399614
metabolic syndrome older adults elderly prevalence Vietnam systematic review meta-analysis

Minxin He, Haibin Zhou, Xiangyu Wang, Mingrui Li, Tie Chong

Purpose: Early diagnosis of tumor recurrence or metastasis is critical for prolonging survival in patients with tumor. Such diagnosis requires not only high accuracy and flexibility but also clinical ...

Research Square 2026-04-21 rs-9434036
renal cell carcinoma circulating tumor cells blood cell counts prognosis inflammation-related indicator

Matei mselle, Vickfarajaeli Daudi

Background Neonatal sepsis caused by Klebsiella pneumoniae remains a major contributor to morbidity and mortality worldwide, particularly in neonatal intensive care units (NICUs). The emergence of car...

Research Square 2026-04-21 rs-9397022
Neonatal sepsis Klebsiella pneumoniae carbapenem resistance meropenem antimicrobial susceptibility testing in vitro–in vivo discordance

Dun Liu, Aierken Rehemutula, Zihao Chen, Yu Si, Hongyu Zhou, LI LI

Purpose To systematically evaluate the clinical efficacy and safety of antibiotic-loaded calcium sulfate (ALCS) as a local antibiotic delivery system for the treatment of osteomyelitis in adult patien...

Research Square 2026-04-21 rs-9416548
Osteomyelitis Antibiotic-loaded calcium sulfate Local antibiotic delivery Meta-analysis Systematic review Infection eradication Bone healing Biodegradable carrier

Fabio Grassia, Muhammad Riaz

Background Trigeminal neuralgia (TN) is one of the most severe pain syndromes in clinical medicine, with a prevalence of 4–13 per 100,000 annually. A substantial proportion of patients require surgica...

Research Square 2026-04-21 rs-9456237
trigeminal neuralgia scoping review microvascular decompression stereotactic radiosurgery percutaneous rhizotomy neurovascular conflict PRISMA-ScR clinical algorithm ICHD-3 peripheral nerve stimulation
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