1,010 results found

Abdi Leta, Gamachu Diba

Background Oral administration is the preferred route for drug delivery due to convenience and patient compliance, yet its efficacy is hampered by low solubility and enzymatic degradation. Nanoparticu...

Research Square 2026-04-21 rs-9452361
nanoparticles oral bioavailability drug delivery systems pharmacokinetics

Shukhrat Djabbarov, Abdusaid Yuldashov, Bakhrom Abdullaev, Irina Soboleva, Шерзод Файзибаев, Nargiza Yuldashova, Nassim Rustamov

The safe operation of heavy freight trains on steep mountain railway sections depends on effective control of longitudinal in-train forces during start-up and traction transitions. This study investig...

Scientific Reports 2026-04-21 rs-9364175
longitudinal train dynamics coupler force freight train steep gradient field validation MSC Adams

Aisha Ghazanfar, Saba Zaidi, Shafiq Ur Rehman, Hazim Brohi

Introduction: Pulmonary arteriovenous malformations (PAVMs) are abnormal vascular connections that predispose to paradoxical embolism and brain abscess formation. They often remain undetected until se...

Research Square 2026-04-21 rs-9335231
Hereditary Hemorrhagic Telangiectasia Brain abscess Pulmonary Arteriovenous Malformation paradoxical embolism

Tien Nguyen

Background Metabolic syndrome (MetS) is common in older adults and is associated with cardiovascular disease, type 2 diabetes, and functional decline. In Vietnam, evidence on MetS in older adults is s...

BMC Geriatrics 2026-04-21 rs-9399614
metabolic syndrome older adults elderly prevalence Vietnam systematic review meta-analysis

Kamna Redhu, Ajay Kumar, Jagdish Parshad, Meena Sindhu, Ravinder Kumar, Sushil Nagar, Suruchi Sangwan, Monika Jangra, Rajbala Yadav

Metal-based nanoparticles are known for their ecotoxicological and phytotoxic effects, impairing plant growth and development. However, several nanoparticles, including those of zinc, are essential fo...

Discover Agriculture 2026-04-21 rs-9231087
Zinc oxide nanoparticles Biofertilizer Rhizobium Characterization Mungbean

James F. White, Walter A. Goldstein, Colin Treiber, Clara Zinky, Julian Mayfield

Rhizophagy provides wild plant species with nutrients through bacterial assimilation.  We evaluated inbreds which had been developed under nutrient-limited, biodynamic-organic farming conditions by th...

Research Square 2026-04-21 rs-9131646
endophyte colonization trichomes root cap cells mucilage root health rhizophagy

Minxin He, Haibin Zhou, Xiangyu Wang, Mingrui Li, Tie Chong

Purpose: Early diagnosis of tumor recurrence or metastasis is critical for prolonging survival in patients with tumor. Such diagnosis requires not only high accuracy and flexibility but also clinical ...

Research Square 2026-04-21 rs-9434036
renal cell carcinoma circulating tumor cells blood cell counts prognosis inflammation-related indicator

Matei mselle, Vickfarajaeli Daudi

Background Neonatal sepsis caused by Klebsiella pneumoniae remains a major contributor to morbidity and mortality worldwide, particularly in neonatal intensive care units (NICUs). The emergence of car...

Research Square 2026-04-21 rs-9397022
Neonatal sepsis Klebsiella pneumoniae carbapenem resistance meropenem antimicrobial susceptibility testing in vitro–in vivo discordance

Dun Liu, Aierken Rehemutula, Zihao Chen, Yu Si, Hongyu Zhou, LI LI

Purpose To systematically evaluate the clinical efficacy and safety of antibiotic-loaded calcium sulfate (ALCS) as a local antibiotic delivery system for the treatment of osteomyelitis in adult patien...

Research Square 2026-04-21 rs-9416548
Osteomyelitis Antibiotic-loaded calcium sulfate Local antibiotic delivery Meta-analysis Systematic review Infection eradication Bone healing Biodegradable carrier

Fabio Grassia, Muhammad Riaz

Background Trigeminal neuralgia (TN) is one of the most severe pain syndromes in clinical medicine, with a prevalence of 4–13 per 100,000 annually. A substantial proportion of patients require surgica...

Research Square 2026-04-21 rs-9456237
trigeminal neuralgia scoping review microvascular decompression stereotactic radiosurgery percutaneous rhizotomy neurovascular conflict PRISMA-ScR clinical algorithm ICHD-3 peripheral nerve stimulation
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